KIMA - Korea International Medical Association


Seoul National University Hospital, make stem cells by collecting blood

February 24,2020

Professor Kim, Hyo-soo and Yang, Han-mo of Seoul National University Hospital have discovered the world's first Circulating Multipotent Stem cell (CiMS), the origin of the endocardium. It is a technology that can make Induced Pluripotent Stem Cells by obtaining own stem cells similar to cord blood with blood collection. The study was published in Biomaterials (IF; 10.4), a leading biomedical journal.


Previously, stem cells were inhaled by culturing skin tissue to obtain stem cells or by inserting a needle into the bone marrow. However, after 12 years of research, a team of researchers at Seoul National University Hospital, who discovered stem cells during peripheral blood culture, succeeded in culturing and extracting stem cells with only 10cc of peripheral blood. All stem cells in the blood have been known to originate from the bone marrow. The team believes that the newly discovered stem cells were from other organs, and collected blood samples from patients with liver, kidney, bone marrow and heart transplants for genetic analysis. As a result, only in cardiac transplant patients, their stem cells were cultured before transplantation, but after transplantation, cardiac donor-derived stem cells were cultured. Patients who transplanted liver, kidney, and bone marrow had only CiMS with their own genotype before and after transplantation. The researchers explain that the CiMS, which is attached to the endocardium, falls off, circulates through the blood, settles in damaged tissues, and differentiates and helps regeneration.

CiMS stem cells can be differentiated into various cells such as nerves, liver, and muscles. In particular, it's much easier and faster than using dermal capillary to make pluripotent stem cells. The team used these induced pluripotent stem cells to multiply differentiation into cardiomyocytes, vascular smooth muscle cells, and vascular endothelial cells. Animal testing has confirmed excellent effects. The team multiplied CiMS stem cells cultured in peripheral blood 12 years ago and stored them in a nitrogen tank like cord blood. Recently they thawed and cultivated them and they have grown healthy. Professor Kim, Hyo-soo (Cardiology) said, 'If you simply collect 10cc of peripheral blood and culture CiMS stem cells, you can keep them in unlimited freeze and freeze like cord blood and thaw when you need them,'. Currently, cord blood collected from newborns at birth can be stored for 10-15 years and used alone, but now a new way is available for adults to use as cord blood using CiMS stem cells.